1321827-45-5
1321827-45-5
Chemical Structure
SBI-0640726
- CAS No.: 1321827-45-5
- Formula:C23H15ClN2O2
- Molecular Weight:386.83
InChIKey: KSDWHCKHPLWNBX-ZRDIBKRKSA-N
SMILES: O=C(C1=C(C2=CC=CC=C2)C3=C(C=CC(Cl)=C3)NC1=O)/C=C/C4=CC=CC=N4
Biological Activity: SBI-0640726 is an eIF4G1 inhibitor with antiproliferative activity in melanoma. SBI-0640726 disrupts the eIF4F translation initiation complex by inhibiting AKT and NF-kB signaling pathways. SBI-0640726 inhibits the growth of NRAS and BRAF mutant melanoma in vitro[1].
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SBI-0640726 | 99.57% | SBI-0640726 is an eIF4G1 inhibitor with antiproliferative activity in melanoma. SBI-0640726 disrupts the eIF4F translation initiation complex by inhibiting AKT and NF-kB signaling pathways. SBI-0640726 inhibits the growth of NRAS and BRAF mutant melanoma in vitro. | ||||||||||||||||||||
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