132414-02-9
Chemical Structure
Alosetron (Hydrochloride(1:X))
Synonym(s): GR 68755 (Hydrochloride(1:X)); GR 68755X (Hydrochloride(1:X))
- CAS No.: 132414-02-9
- Formula:C17H18N4O.xClH
- Molecular Weight:N/A
SMILES: O=C1N(CC2=C(NC=N2)C)CCC(N3C)=C1C4=C3C=CC=C4.[x HCl]
Biological Activity: Alosetron (GR 68755) Hydrochloride(1:X) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride(1:X) is used for the research of irritable bowel syndrome (IBS). Alosetron Hydrochloride(1:X) blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron Hydrochloride(1:X) attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects[1][2].
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Alosetron (Hydrochloride(1:X)) | Alosetron (GR 68755) Hydrochloride(1:X) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride(1:X) is used for the research of irritable bowel syndrome (IBS). Alosetron Hydrochloride(1:X) blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron Hydrochloride(1:X) attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects. | |||||||||||||||||||||
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