132609-35-9
Chemical Structure
Sapurimycin
Synonym(s): Antibiotic DC 116
- CAS No.: 132609-35-9
- Formula:C25H18O9
- Molecular Weight:462.41
IUPAC Name: 2-(8,11-dihydroxy-2-((2S,3S)-2-methyl-3-((Z)-prop-1-en-1-yl)oxiran-2-yl)-4,7,12-trioxo-7,12-dihydro-4H-naphtho[2,3-h]chromen-5-yl)acetic acid
InChIKey: MAUMGBVGKFVQCP-NAVFIMFESA-N
SMILES: O=C(O)CC(C=C1C(C2=C3C(O)=CC=C2O)=O)=C(C(C=C([C@@]4(C)O[C@H]4/C=C\C)O5)=O)C5=C1C3=O
Biological Activity: Sapurimycin is an antitumor antibiotic isolated from Streptomyces DO-116 and belongs to the capramycin family. Sapurimycin exhibits potent activity against Gram-positive bacteria and exhibits significant antitumor effects against leukemia P388 and sarcoma 180 in mouse models. In vitro studies have shown that Sapurimycin can induce single-strand breaks in supercoiled plasmid DNA[1].
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Sapurimycin | Sapurimycin is an antitumor antibiotic isolated from Streptomyces DO-116 and belongs to the capramycin family. Sapurimycin exhibits potent activity against Gram-positive bacteria and exhibits significant antitumor effects against leukemia P388 and sarcoma 180 in mouse models. In vitro studies have shown that Sapurimycin can induce single-strand breaks in supercoiled plasmid DNA. | |||||||||||||||||||||
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