132722-74-8
Chemical Structure
Pirsidomine
- CAS No.: 132722-74-8
- Formula:C17H22N4O3
- Molecular Weight:330.38
IUPAC Name: (3-((2R,6S)-2,6-dimethylpiperidin-1-yl)-1,2,3-oxadiazol-3-ium-5-yl)(4-methoxybenzoyl)amide
InChIKey: TXPUBJSOHAMNEI-BETUJISGSA-N
SMILES: C[C@H]1N([N+]2=NOC([N-]C(C3=CC=C(OC)C=C3)=O)=C2)[C@H](CCC1)C
Biological Activity: Pirsidomine is a nitric oxide donor. Pirsidomine is a sydnonimine compound. Pirsidomine can transform into a nitric oxide-releasing metabolite in vivo. Pirsidomine prevents occlusion-induced increase in flow in the non-occluded circumflex coronary artery and significantly reduces the blood flow in non-ischemic areas in myocardial infarction dog model. Pirsidomine can be studied in research on cardiovascular diseases[1][2].
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Pirsidomine | Pirsidomine is a nitric oxide donor. Pirsidomine is a sydnonimine compound. Pirsidomine can transform into a nitric oxide-releasing metabolite in vivo. Pirsidomine prevents occlusion-induced increase in flow in the non-occluded circumflex coronary artery and significantly reduces the blood flow in non-ischemic areas in myocardial infarction dog model. Pirsidomine can be studied in research on cardiovascular diseases. | |||||||||||||||||||||
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References
- [1]. Martorana, P. A., et al., (1994). Antiischemic effects of pirsidomine, a new nitric oxide donor. European journal of pharmacology, 257(3), 267-273. [Content Brief]
- [2]. Stengele, E., et al., (1996). Short-term hemodynamic, anti-ischemic, and antianginal effects of pirsidomine, a new sydnonimine. The American journal of cardiology, 77(11), 937-941. [Content Brief]
