132798-26-6
132798-26-6
Chemical Structure
LG 6-101
- CAS No.: 132798-26-6
- Formula:C22H32ClNO3S
- Molecular Weight:426.01
IUPAC Name: 1-(3-(3-(isobutylamino)-2-methoxypropoxy)-4-methylthiophen-2-yl)-3-phenylpropan-1-one hydrochloride
InChIKey: DTIZUFNQHYOWFZ-UHFFFAOYSA-N
SMILES: O=C(CCC1=CC=CC=C1)C2=C(OCC(CNCC(C)C)OC)C(C)=CS2.Cl
Biological Activity: LG 6-101 is an orally active antiarrhythmic agent. LG 6-101 shows strong antiarrhythmic effects in a coronary-artery-ligation model of rats, better than Propafenone (HY-B0432). LG 6-101 also delays the occurence of ventricular premature beat (VPB)'s and has protective effects against cardiac arrest caused by aconitine[1][2].
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LG 6-101 | LG 6-101 is an orally active antiarrhythmic agent. LG 6-101 shows strong antiarrhythmic effects in a coronary-artery-ligation model of rats, better than Propafenone (HY-B0432). LG 6-101 also delays the occurence of ventricular premature beat (VPB)'s and has protective effects against cardiac arrest caused by aconitine. | |||||||||||||||||||||
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References
- [1]. Wascher TC, et al. LG 6-101 and LG 6-102, two new propafenone-related antiarrhythmic agents with good oral activity in rats. Naunyn Schmiedebergs Arch Pharmacol. 1992 Apr;345(4):473-7. [Content Brief]
- [2]. Wascher TC, et al. Antiarrhythmic effects of two new propafenone related drugs. A study on four animal models of arrhythmia. Arzneimittelforschung. 1991 Feb;41(2):119-24. [Content Brief]
