1329556-63-9
Chemical Structure
Droxidopa-13C2,15N hydrochloride
Synonym(s): L-DOPS-13C2,15N hydrochloride; DOPS-13C2,15N hydrochloride; SM5688-13C2,15N hydrochloride
- CAS No.: 1329556-63-9
- Formula:C713C2H12Cl15NO5
- Molecular Weight:252.63
IUPAC Name: (2S,3R)-2-(amino-15N)-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic-1,2-13C2 acid hydrochloride
InChIKey: FFEWFMCABUNGJJ-OPABSIBTSA-N
SMILES: O[13C]([13C@@H]([15NH2])[C@@H](C1=CC(O)=C(C=C1)O)O)=O.Cl
Biological Activity: Droxidopa-13C2,15N (hydrochloride) is deuterium labeled Droxidopa. Droxidopa(L-DOPS), the mixture of Droxidopa (w/w80%) and Pharmaceutical starch (w/w20%), acts as a proagent to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); Droxidopa(L-DOPS) is capable of crossing the protective blood-brain barrier[1][2].
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Droxidopa-13C2,15N hydrochloride | Droxidopa-13C2,15N (hydrochloride) is deuterium labeled Droxidopa. Droxidopa(L-DOPS), the mixture of Droxidopa (w/w80%) and Pharmaceutical starch (w/w20%), acts as a proagent to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); Droxidopa(L-DOPS) is capable of crossing the protective blood-brain barrier. | |||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Coll M, et al. Droxidopa, an oral norepinephrine precursor, improves hemodynamic and renal alterations of portal hypertensive rats. Hepatology. 2012 Nov;56(5):1849-60. [Content Brief]
