1329802-06-3
1329802-06-3
Chemical Structure
Memantine-d3 hydrochloride
- CAS No.: 1329802-06-3
- Formula:C12H19D3ClN
- Molecular Weight:218.78
IUPAC Name: (1S,3R,5S,7S)-3-methyl-5-(methyl-d3)adamantan-1-amine hydrochloride
InChIKey: LDDHMLJTFXJGPI-ZILFXZMLSA-N
SMILES: N[C@]1(C2)C[C@]3(C)C[C@@H](C[C@@]2(C([2H])([2H])[2H])C3)C1.[H]Cl
Biological Activity: Memantine-d3 (hydrochloride) is deuterium labeled Memantine. Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist. Memantine can be used for the research of moderate-to-severe Alzheimer's disease (AD)[1][2][3].
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Memantine-d3 hydrochloride | Memantine-d3 (hydrochloride) is deuterium labeled Memantine. Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist. Memantine can be used for the research of moderate-to-severe Alzheimer's disease (AD). | |||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Marotta G, et al. Memantine Derivatives as Multitarget Agents in Alzheimer's Disease. Molecules. 2020;25(17):4005. Published 2020 Sep 2. [Content Brief]
- [3]. Pinho J, et al. Enhanced LTP in aged rats: Detrimental or compensatory?. Neuropharmacology. 2017;114:12-19. [Content Brief]
