1329837-33-3
1329837-33-3
Chemical Structure
Tonabersat-d6
Synonym(s): SB-220453-d6
- CAS No.: 1329837-33-3
- Formula:C20H13D6ClFNO4
- Molecular Weight:397.86
InChIKey: XLIIRNOPGJTBJD-CVQIQVDISA-N
SMILES: O=C(C1=CC(Cl)=C(C=C1)F)N[C@H]2C3=CC(C(C)=O)=CC=C3OC(C([2H])([2H])[2H])([C@H]2O)C([2H])([2H])[2H]
Biological Activity: Tonabersat-d6 (SB-220453-d6) is deuterium labeled Tonabersat. Tonabersat (SB-220453) is a gap-junction modulator. Tonabersat prevents inflammatory damage in the central nervous system[1][2][3].
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Tonabersat-d6 | Tonabersat-d6 (SB-220453-d6) is deuterium labeled Tonabersat. Tonabersat (SB-220453) is a gap-junction modulator. Tonabersat prevents inflammatory damage in the central nervous system. | |||||||||||||||||||||
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Tonabersat | 99.88% | Tonabersat (SB-220453) is a gap-junction modulator. Tonabersat prevents inflammatory damage in the central nervous system. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Chen Q, et al. Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature. 2016 May 18;533(7604):493-8. [Content Brief]
- [3]. Silberstein SD, et al. Tonabersat, a gap-junction modulator: efficacy and safety in two randomized, placebo-controlled, dose-ranging studies of acute migraine. Cephalalgia. 2009 Nov;29 Suppl 2:17-27. [Content Brief]
