1331754-16-5
1331754-16-5
Chemical Structure
A6770
- CAS No.: 1331754-16-5
- Formula:C6H8N2O2
- Molecular Weight:140.14
IUPAC Name: 1-(5-(hydroxymethyl)-1H-imidazol-2-yl)ethan-1-one
InChIKey: JXDVIQLWMKAZBS-UHFFFAOYSA-N
SMILES: CC(C1=NC=C(CO)N1)=O
Biological Activity: A6770 is an orally active, potent sphingosine 1-phosphate (S1P) lyase (S1PL) inhibitor. A6770 is phosphorylated and the phosphorylated form directly inhibits S1P lyased.A6770, a potential key metabolite of THI, induces a [3H]dhS1P increase[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
A6770 | 98.23% | A6770 is an orally active, potent sphingosine 1-phosphate (S1P) lyase (S1PL) inhibitor. A6770 is phosphorylated and the phosphorylated form directly inhibits S1P lyased.A6770, a potential key metabolite of THI, induces a [3H]dhS1P increase. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Mamoru Ohtoyo, et al. Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1-Phosphate Levels. Lipids. 2016 Oct;51(10):1207-1216. [Content Brief]
- [2]. Mamoru Ohtoyo, et al. Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate. Cell Chem Biol. 2016 May 19;23(5):555-560. [Content Brief]
