1335113-30-8
Chemical Structure
EBOV-IN-1
- CAS No.: 1335113-30-8
- Formula:C34H43N3O5
- Molecular Weight:573.72
IUPAC Name: methyl 4-((2-((4-((2-(adamantan-1-yl)acetyl)glycyl)piperazin-1-yl)methyl)phenoxy)methyl)benzoate
InChIKey: KSISWIVDFITFKQ-UHFFFAOYSA-N
SMILES: COC(=O)C1=CC=C(COC2=CC=CC=C2CN2CCN(C(=O)CNC(=O)CC34CC5CC(CC(C5)C3)C4)CC2)C=C1
Biological Activity: EBOV-IN-1 (com 3.47) is an adamantane dipeptide piperazine and an inhibitor of Ebola virus (EBOV). EBOV-IN-1 targets Niemann-Pick C1 (NPC1) and inhibits its binding to the EBOV glycoprotein (GP) that activates and mediates viral penetration into host cells, thereby inhibiting EBOV infection. EBOV-IN-1 inhibits pseudotyped EBOV infection with an IC50 of 13 nM[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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EBOV-IN-1 | 98.66% | EBOV-IN-1 (com 3.47) is an adamantane dipeptide piperazine and an inhibitor of Ebola virus (EBOV). EBOV-IN-1 targets Niemann-Pick C1 (NPC1) and inhibits its binding to the EBOV glycoprotein (GP) that activates and mediates viral penetration into host cells, thereby inhibiting EBOV infection. EBOV-IN-1 inhibits pseudotyped EBOV infection with an IC50 of 13 nM. | ||||||||||||||||||||
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