1335145-56-6
Chemical Structure
A-424274
- CAS No.: 1335145-56-6
- Formula:C14H15N3
- Molecular Weight:225.29
IUPAC Name: 3-((1S,5S)-3,6-diazabicyclo[3.2.0]heptan-3-yl)quinoline
InChIKey: PKTSUYRXYHYCBU-SMDDNHRTSA-N
SMILES: [H][C@]12CN(C3=CC4=CC=CC=C4N=C3)C[C@@]1([H])NC2
Biological Activity: A-424274 is a positive allosteric modulator of the α4β2 neuronal nicotinic acetylcholine receptor with activity to enhance the efficacy of analgesics. A-424274 selectively enhances the potency of a range of nicotinic acetylcholine receptor agonists at the α4β2 receptor and, in preclinical models, co-administration with an α4β2 PAM significantly enhances the analgesic efficacy of ABT-594 at clinically well-tolerated doses in humans.
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A-424274 | A-424274 is a positive allosteric modulator of the α4β2 neuronal nicotinic acetylcholine receptor with activity to enhance the efficacy of analgesics. A-424274 selectively enhances the potency of a range of nicotinic acetylcholine receptor agonists at the α4β2 receptor and, in preclinical models, co-administration with an α4β2 PAM significantly enhances the analgesic efficacy of ABT-594 at clinically well-tolerated doses in humans. | |||||||||||||||||||||
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