133525-01-6
Chemical Structure
Zidovudine O-β-D-glucuronide sodium
Synonym(s): 3'-Azido-3'-deoxythymidine β-D-glucuronide sodium
- CAS No.: 133525-01-6
- Formula:C16H20N5NaO10
- Molecular Weight:465.35
IUPAC Name: sodium (2S,3S,4S,5R,6R)-6-(((2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate
InChIKey: ANFPIJBVCFGZOF-UACHAAAFSA-M
SMILES: O=C(NC1=O)N(C=C1C)[C@](C[C@@H]2N=[N+]=[N-])([H])O[C@@H]2CO[C@@H]([C@@H]([C@H]3O)O)O[C@@H]([C@H]3O)C(O[Na])=O
Biological Activity: Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine[1][2][3].
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Zidovudine O-β-D-glucuronide sodium | 99.05% | Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine. | ||||||||||||||||||||
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Zidovudine O-β-D-glucuronide-d3 sodium | Zidovudine O-β-D-glucuronide-d3 sodium (3'-Azido-3'-deoxythymidine β-D-glucuronide-d3 sodium) is a deuterium labeled Zidovudine O-β-D-glucuronide sodium (HY-137522). Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine. | |||||||||||||||||||||
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References
- [1]. Walsky RL, et al. Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors. Drug Metab Dispos. 2012;40(5):1051-1065. [Content Brief]
- [2]. Di Marco MP, et al. On-line deconjugation of glucuronides using an immobilized enzyme reactor based upon beta-glucuronidase. J Chromatogr B Biomed Sci Appl. 1998;715(2):379-386. [Content Brief]
- [3]. Tahara, T., et al. A novel 11C-labeled thymidine analog, [11C]AZT, for tumor imaging by positron emission tomography. EJNMMI Res 5, 45 (2015).
