133550-18-2
133550-18-2
Chemical Structure
AG 538
- CAS No.: 133550-18-2
- Formula:C16H11NO5
- Molecular Weight:297.26
IUPAC Name: (E)-2-(3,4-dihydroxybenzoyl)-3-(3,4-dihydroxyphenyl)acrylonitrile
InChIKey: CANOJKGQDCJDOX-VZUCSPMQSA-N
SMILES: N#C/C(C(C1=CC=C(O)C(O)=C1)=O)=C\C2=CC=C(O)C(O)=C2
Biological Activity: AG 538 is a potent, competitive inhibitor of IGF-1 receptor kinase, with an IC50 of 400 nM[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AG 538 | 98.99% | AG 538 is a potent, competitive inhibitor of IGF-1 receptor kinase, with an IC50 of 400 nM. | ||||||||||||||||||||
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AGL-2263 | 98.31% | AGL-2263 is an insulin receptor and insulin-like growth factor (IGF) receptor inhibitor. | ||||||||||||||||||||
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I-OMe-Tyrphostin AG 538 | 98.03% | I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells.?I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50?of 1 μM. | ||||||||||||||||||||
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EGFR-IN-16 | EGFR-IN-16 (compound 3) is a potent EGFR inhibitor with pIC50 of 4.85 and 4.74 for EGFR and HER-2, respectively. | |||||||||||||||||||||
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YZL-51N | 95.0% | YZL-51N is a selective SIRT7 inhibitor with IC50 value of 12.71 μM. YZL-51N disrupts SIRT7 enzyme activity by occupying the NAD+ binding pocket, thereby weakening DNA damage repair and inhibiting cancer cell survival. YZL-51N possesses anti-tumor activity and can be used in cancer research. | ||||||||||||||||||||
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Butein | 99.64% | Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4. Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Butein is a SIRT1 activator (STAC). | ||||||||||||||||||||
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Z17544625 | Z17544625 is a Fascin inhibitor. Z17544625 has a strong binding capacity to fascin and inhibits Actin bundling. Z17544625 significantly reduces proliferation and impairs migration of CRC cells. Z17544625 can be used for cancer, especially colorectal cancer (CRC) research. | |||||||||||||||||||||
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Tyrphostin AG-808 | Tyrphostin AG-808 is a protein tyrosine kinase inhibitor that does not reduce neointimal formation. Perivascular implantation of Tyrphostin AG-808 causes medial damage in rats. | |||||||||||||||||||||
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Okanin | 99.76% | Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways. | ||||||||||||||||||||
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Eriodictyol chalcone | 97.25% | Eriodictyol chalcone is an antioxidant that inhibits multiple key enzymes including 5-LOX (IC50=0.043 μM), aromatase/CYP19A1 (IC50=2.8 μM), PTPase 1B (IC50=1.26 μM), and COX (IC50=34 μM). Eriodictyol chalcone exhibits excellent free radical scavenging activity. Eriodictyol chalcone not only inhibits the growth of plasmodia and enhances the efficacy of Artemisinin (HY-B0094), but also reduces depression-like behaviors in animal models. Eriodictyol chalcone serves as a biosynthetic precursor for Aureusidin (HY-N9834). Eriodictyol chalcone is a potential dietary supplement and herbicide, and it can be applied to research on malaria, depression, breast cancer and other related diseases. | ||||||||||||||||||||
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N-(E)-Caffeoyldopamine | N-(E)-Caffeoyldopamine is an inhibitor of α-glucosidase that can be purified from Clerodendranthus Spicatus. N-(E)-Caffeoyldopamine shows a 53.73% inhibitory activity againstα-glucosidase. N-(E)-Caffeoyldopamine can be studied in diabetes research. | |||||||||||||||||||||
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