133613-71-5
133613-71-5
Chemical Structure
Galiellalactone
- CAS No.: 133613-71-5
- Formula:C11H14O3
- Molecular Weight:194.23
IUPAC Name: (2aR,2a1S,4aR,6S)-2a1-hydroxy-6-methyl-2a1,3,4,4a,5,6-hexahydroindeno[1,7-bc]furan-1(2aH)-one
InChIKey: SOIISBQQYAGDKM-QJSROADHSA-N
SMILES: O=C1C2=C[C@@H](C)C[C@@]3([H])CC[C@@]([C@@]23O)([H])O1
Biological Activity: Galiellalactone is a is a small non-toxic and non-mutagenic fungal metabolite, a selective inhibitor of STAT3 signaling, with an IC50 of 250-500 nM. Galiellalactone can be used to research castration-resistant prostate cancer[1][2][3].
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Galiellalactone | Galiellalactone is a is a small non-toxic and non-mutagenic fungal metabolite, a selective inhibitor of STAT3 signaling, with an IC50 of 250-500 nM. Galiellalactone can be used to research castration-resistant prostate cancer. | |||||||||||||||||||||
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References
- [1]. Hellsten R, et, al. Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated Stat3. Prostate. 2008 Feb 15; 68(3): 269-80. [Content Brief]
- [2]. Doncow DN, et, al. Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells. J Biol Chem. 2014 Jun 6; 289(23): 15969-78. [Content Brief]
- [3]. Weidler M, et, al. Inhibition of interleukin-6 signaling by galiellalactone. FEBS Lett. 2000 Oct 27; 484(1): 1-6. [Content Brief]
