133669-72-4
Chemical Structure
Sjc 13
- CAS No.: 133669-72-4
- Formula:C17H18N3NaO4
- Molecular Weight:351.33
IUPAC Name: (E)-2-cyano-3-(2,8-diisopropoxyimidazo[1,2-a]pyridin-3-yl)acrylic acid, sodium salt
InChIKey: GOVZZJGFRYAUKY-MXZHIVQLSA-M
SMILES: N#C/C(C(O[Na])=O)=C\C1=C(OC(C)C)N=C2C(OC(C)C)=CC=CN21
Biological Activity: Sjc 13 is an inhibitor of E-selectin and VCAM-1, with IC50 values of 150 μg/mL and 115 μg/mL, respectively. Sjc 13 prevents neutrophil migration and adhesion by selectively inhibiting the expression and mRNA synthesis of E-selectin and VCAM-1 in LPS-stimulated endothelial cells, thereby protecting against LPS-induced lethal shock. Sjc 13 is applicable to the study of septic shock[1][2].
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Sjc 13 | Sjc 13 is an inhibitor of E-selectin and VCAM-1, with IC50 values of 150 μg/mL and 115 μg/mL, respectively. Sjc 13 prevents neutrophil migration and adhesion by selectively inhibiting the expression and mRNA synthesis of E-selectin and VCAM-1 in LPS-stimulated endothelial cells, thereby protecting against LPS-induced lethal shock. Sjc 13 is applicable to the study of septic shock. | |||||||||||||||||||||
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References
- [1]. Sakai A, et al. Protection against septic shock in mice with SJC13, an azaindolidine derivative that is a cell adhesion molecule inhibitor. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 1996 Sep;45(9):448-51.
- [2]. Sakai A, et al. Inhibition of endothelial cell adhesion molecule expression with SJC13, an azaindolidine derivative, in vitro. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 1996 May;45(5):224-9.
