1337531-05-1
1337531-05-1
Chemical Structure
GSK-067
Synonym(s): GSK2593067A
- CAS No.: 1337531-05-1
- Formula:C26H21N5OS
- Molecular Weight:451.55
IUPAC Name: 1-(5-(4-amino-7-(1H-pyrazol-4-yl)thieno[3,2-c]pyridin-3-yl)indolin-1-yl)-2-phenylethan-1-one
InChIKey: NXZHFEXEUNSRPZ-UHFFFAOYSA-N
SMILES: O=C(N1C2=CC=C(C=C2CC1)C3=CSC=4C(=CN=C(N)C43)C=5C=NNC5)CC=6C=CC=CC6
Biological Activity: GSK-067 (GSK2593067A) is an inhibitor of necroptosis. GSK-067 inhibits PERK-catalyzed phosphorylation of eIF2α. GSK-067 can be used for research on pancreatic cancer[1][2][3].
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GSK-067 | GSK-067 (GSK2593067A) is an inhibitor of necroptosis. GSK-067 inhibits PERK-catalyzed phosphorylation of eIF2α. GSK-067 can be used for research on pancreatic cancer. | |||||||||||||||||||||
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References
- [1]. Liu B, et al. WO2023034236A1. PCT/US2022/041936. Published 2023 Mar 9.
- [2]. Axten JM, et al. Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). Journal of medicinal chemistry. 2012 Aug 23;55(16):7193-207. [Content Brief]
- [3]. Zhou T, et al. Identification of a novel class of RIP1/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models. Cell death & disease. 2019 Mar 06;10(3):226. [Content Brief]
