1338231-09-6
Chemical Structure
NOTA-NHS ester
- CAS No.: 1338231-09-6
- Formula:C16H24N4O8
- Molecular Weight:400.38
IUPAC Name: 2,2'-(7-(2-((2,5-dioxopyrrolidin-1-yl)oxy)-2-oxoethyl)-1,4,7-triazonane-1,4-diyl)diacetic acid
InChIKey: UYDHNYKGXODDAV-UHFFFAOYSA-N
SMILES: O=C(O)CN1CCN(CC(ON2C(CCC2=O)=O)=O)CCN(CC(O)=O)CC1
Biological Activity: NOTA-NHS ester is a chelating agent. NOTA-NHS ester can be coupled with T140 (HY-P4810) to produce NOTA-T140. NOTA-T140 can be radiolabeled with Al[18F]. The uptake of Al[18F]NOTA-T140 in tumors is correlated with the expression level of CXCR4. Al[18F]NOTA-T140 can be used in tumor PET imaging studies. NOTA-NHS ester can be used for fluorescent labeling[1][2][3].
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NOTA-NHS ester | 90.0% | NOTA-NHS ester is a chelating agent. NOTA-NHS ester can be coupled with T140 (HY-P4810) to produce NOTA-T140. NOTA-T140 can be radiolabeled with Al[18F]. The uptake of Al[18F]NOTA-T140 in tumors is correlated with the expression level of CXCR4. Al[18F]NOTA-T140 can be used in tumor PET imaging studies. NOTA-NHS ester can be used for fluorescent labeling. | ||||||||||||||||||||
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References
- [1]. Lang L, et al. Stability analysis of glutamic acid linked peptides coupled to NOTA through different chemical linkages. Mol Pharm. 2014 Nov 3;11(11):3867-74. [Content Brief]
- [2]. Chen CJ, et al. 68Ga-labelled NOTA-RGD-GE11 peptide for dual integrin and EGFR-targeted tumour imaging. Nucl Med Biol. 2019 Jan-Feb;68-69:22-30. [Content Brief]
- [3]. Yan X, et al. Al[18F]NOTA-T140 Peptide for Noninvasive Visualization of CXCR4 Expression. Mol Imaging Biol. 2016 Feb;18(1):135-42. [Content Brief]
