134052-66-7
134052-66-7
Chemical Structure
(RS)-4C3HPG
Synonym(s): 4-Carboxy-3-hydroxyphenylglycine
- CAS No.: 134052-66-7
- Formula:C9H9NO5
- Molecular Weight:211.17
IUPAC Name: 4-(amino(carboxy)methyl)-2-hydroxybenzoic acid
InChIKey: GXZSAQLJWLCLOX-UHFFFAOYSA-N
SMILES: O=C(O)C(N)C1=CC=C(C(O)=O)C(O)=C1
Biological Activity: (RS)-4C3HPG (4-Carboxy-3-hydroxyphenylglycine) is an effective competitive antagonist at the metabotropic glutamate receptor 1 (mGluR1) in the central nervous system, and it is also an agonist at mGluR2/3. (RS)-4C3HPG exhibits neuroprotective effects in an acute global ischemia rat model[1][2].
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(RS)-4C3HPG | (RS)-4C3HPG (4-Carboxy-3-hydroxyphenylglycine) is an effective competitive antagonist at the metabotropic glutamate receptor 1 (mGluR1) in the central nervous system, and it is also an agonist at mGluR2/3. (RS)-4C3HPG exhibits neuroprotective effects in an acute global ischemia rat model. | |||||||||||||||||||||
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References
- [1]. Gerber U, et al. 4C3HPG (RS-4-carboxy-3-hydroxyphenylglycine), a weak agonist at metabotropic glutamate receptors, occludes the action of trans-ACPD in hippocampus. Eur J Pharmacol. 1992 Oct 20;221(2-3):401-2. [Content Brief]
- [2]. Henrich-Noack P, et al. The mGlu receptor ligand (S)-4C3HPG protects neurons after global ischaemia in gerbils. Neuroreport. 1998 Apr 20;9(6):985-8. [Content Brief]
