1346016-43-0
Chemical Structure
RC-33 hydrochloride
- CAS No.: 1346016-43-0
- Formula:C21H28ClN
- Molecular Weight:329.91
IUPAC Name: 1-(3-([1,1'-biphenyl]-4-yl)butyl)piperidine hydrochloride
InChIKey: IYZBMSKKZQBBKD-UHFFFAOYSA-N
SMILES: CC(C1=CC=C(C2=CC=CC=C2)C=C1)CCN3CCCCC3.Cl
Biological Activity: RC-33 hydrochloride is a selective and metabolically stable σ receptor agonist with activity in enhancing nerve growth factor (NGF)-induced neurite outgrowth. Both enantiomers of RC-33 hydrochloride bind to the σ receptor with similar affinity and show almost equal effectiveness as σ receptor agonists. The R-configured enantiomer of RC-33 hydrochloride shows higher liver metabolic stability in the presence of NADPH. RC-33 hydrochloride was selected as the best candidate for further in vivo studies in animal models of amyotrophic lateral sclerosis[1].
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RC-33 hydrochloride | RC-33 hydrochloride is a selective and metabolically stable σ receptor agonist with activity in enhancing nerve growth factor (NGF)-induced neurite outgrowth. Both enantiomers of RC-33 hydrochloride bind to the σ receptor with similar affinity and show almost equal effectiveness as σ receptor agonists. The R-configured enantiomer of RC-33 hydrochloride shows higher liver metabolic stability in the presence of NADPH. RC-33 hydrochloride was selected as the best candidate for further in vivo studies in animal models of amyotrophic lateral sclerosis. | |||||||||||||||||||||
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