1346602-15-0
Chemical Structure
Orotic acid-13C,15N2 monohydrate
Synonym(s): 6-Carboxyuracil-13C,15N2 monohydrate; Vitamin B13-13C,15N2 monohydrate
- CAS No.: 1346602-15-0
- Formula:C413CH615N2O5
- Molecular Weight:177.09
IUPAC Name: 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic-2-13C-1,3-15N2 acid hydrate
InChIKey: YXUZGLGRBBHYFZ-RYBQTAQPSA-N
SMILES: OC(C1=CC([15NH][13C]([15NH]1)=O)=O)=O.O
Biological Activity: Orotic acid-13C,15N2 (monohydrate) is the 13C and 15N labeled Orotic acid[1]. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats[2][3][4].
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Orotic acid-13C,15N2 monohydrate | 99.93% | Orotic acid-13C,15N2 (monohydrate) is the 13C and 15N labeled Orotic acid. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats. | ||||||||||||||||||||
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Orotic acid hydrate (Standard) | ≥98% | Orotic acid (hydrate) (Standard) is the analytical standard of Orotic acid (hydrate) (HY-W016812). This product is intended for research and analytical applications. Orotic acid hydrate is an endogenous metabolite. | ||||||||||||||||||||
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Orotic acid hydrate | 99.94% | Orotic acid hydrate is an endogenous metabolite. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Löffler M, et, al. Orotate (orotic acid): An essential and versatile molecule. Nucleosides Nucleotides Nucleic Acids. [Content Brief]
- [3]. Staretz-Chacham O, et, al. The role of orotic acid measurement in routine newborn screening for urea cycle disorders. J Inherit Metab Dis. 2020 Nov 15. [Content Brief]
- [4]. Durschlag RP, et, al. Orotic acid-induced metabolic changes in the rat. J Nutr. 1980 Apr110(4):816-21. [Content Brief]
