134861-34-0
Chemical Structure
GE 2270A
Synonym(s): MDL 62879
- CAS No.: 134861-34-0
- Formula:C56H55N15O10S6
- Molecular Weight:1290.52
IUPAC Name: (S)-1-((S)-2-(2-((12Z,22Z,42Z,82Z,122Z,7S,11S,18S)-18-((S)-hydroxy(phenyl)methyl)-11-isopropyl-125-(methoxymethyl)-85-methyl-7-(2-(methylamino)-2-oxoethyl)-5,9,13,16-tetraoxo-6,10,14,17-tetraaza-1(4,2),2,4,8,12(2,4)-pentathiazola-3(2,3)-pyridinacyclooctad
InChIKey: JMDULECOHIXMNX-MZHFYNGJSA-N
SMILES: O=C1C2=CSC(C3=CC=C(C4=NC(C5=N[C@@H](CO5)C(N6[C@@H](CCC6)C(N)=O)=O)=CS4)N=C3C7=CSC(C8=CSC([C@](NC(CNC(C9=C(SC([C@@H](NC(C%10=C(C)SC([C@@H](N1)CC(NC)=O)=N%10)=O)C(C)C)=N9)COC)=O)=O)([H])[C@H](C%11=CC=CC=C%11)O)=N8)=N7)=N2
Biological Activity: GE 2270A (MDL 62879) is an antibiotic. GE 2270A inhibits gram-positive bacteria and anaerobes by inhibiting protein synthesis. GE 2270A can be used for the research of infection[1][2].
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GE 2270A | GE 2270A (MDL 62879) is an antibiotic. GE 2270A inhibits gram-positive bacteria and anaerobes by inhibiting protein synthesis. GE 2270A can be used for the research of infection. | |||||||||||||||||||||
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References
- [1]. Landini P, B et al. Inhibition of bacterial protein synthesis by elongation-factor-Tu-binding antibiotics MDL 62,879 and efrotomycin. Biochem J. 1992 May 1;283 ( Pt 3)(Pt 3):649-52. [Content Brief]
- [2]. Anborgh PH, Parmeggiani A. New antibiotic that acts specifically on the GTP-bound form of elongation factor Tu. EMBO J. 1991 Apr;10(4):779-84. [Content Brief]
