1350545-09-3
Chemical Structure
SKLB188
- CAS No.: 1350545-09-3
- Formula:C27H31N9O2
- Molecular Weight:513.59
IUPAC Name: 9-cyclopentyl-N2-(4-(4-methylpiperazin-1-yl)phenyl)-N8-(3-nitrophenyl)-9H-purine-2,8-diamine
InChIKey: XUVALDKZKUYGFZ-UHFFFAOYSA-N
SMILES: O=[N+](C1=CC(NC2=NC3=CN=C(NC4=CC=C(N5CCN(C)CC5)C=C4)N=C3N2C6CCCC6)=CC=C1)[O-]
Biological Activity: SKLB188 is an orally active and potent epidermal growth factor receptor (EGFR) inhibitor (IC50=5 nM). SKLB188 suppresses MEK/Erk and Akt/mTOR signaling pathways to inhibit head and neck squamous cell carcinoma (HNSCC) proliferation and induce caspase-dependent apoptosis. SKLB188 is promising for research of EGFR-overexpressing solid tumors[1].
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SKLB188 | SKLB188 is an orally active and potent epidermal growth factor receptor (EGFR) inhibitor (IC50=5 nM). SKLB188 suppresses MEK/Erk and Akt/mTOR signaling pathways to inhibit head and neck squamous cell carcinoma (HNSCC) proliferation and induce caspase-dependent apoptosis. SKLB188 is promising for research of EGFR-overexpressing solid tumors. | |||||||||||||||||||||
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