1350735-70-4
Chemical Structure
GS-6620
- CAS No.: 1350735-70-4
- Formula:C29H37N6O9P
- Molecular Weight:644.61
IUPAC Name: (2R,3R,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-2-((((S)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl isobutyrate
InChIKey: YAAQYJCOIFNMKX-RSTNYOGXSA-N
SMILES: NC1=NC=NN2C1=CC=C2[C@@]3(C#N)[C@@](O)(C)[C@H](OC(C(C)C)=O)[C@@H](CO[P@](OC4=CC=CC=C4)(N[C@@H](C)C(OC(C)C)=O)=O)O3
Biological Activity: GS-6620 is potent and selective HCV inhibitor. GS-6620 inhibits HCV replication in genotype 1-6 subgenomic replicons and genotype 2a infectious virus, with EC50 values of 0.048-0.68 μM. GS-6620 can be used for the researches of infection and inflammation, such as Hepatitis C Virus (HCV)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GS-6620 | 98.93% | GS-6620 is potent and selective HCV inhibitor. GS-6620 inhibits HCV replication in genotype 1-6 subgenomic replicons and genotype 2a infectious virus, with EC50 values of 0.048-0.68 μM. GS-6620 can be used for the researches of infection and inflammation, such as Hepatitis C Virus (HCV). | ||||||||||||||||||||
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References
- [1]. Joy Y Feng, et al. Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug. Antimicrob Agents Chemother. 2014;58(4):1930-42. [Content Brief]
- [2]. Cho A, et al. Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients. J Med Chem. 2014 Mar 13;57(5):1812-25. [Content Brief]
