1352280-98-8
1352280-98-8
Chemical Structure
Ceralasertib formate
Synonym(s): AZD-6738 formate
- CAS No.: 1352280-98-8
- Formula:C20H24N6O2S.xCH2O2
- Molecular Weight:458.53
SMILES: C[C@H]1N(CCOC1)C2=CC(C3(CC3)[S@@](=N)(C)=O)=NC(C4=C5C(NC=C5)=NC=C4)=N2.OC=O.[F,Cl,Br,I]
Biological Activity: Ceralasertib formate is a potent, selective and orally active ATR inhibitor with an IC50 value of 1 nM. Ceralasertib formate inhibits cell viability and induces DNA damage. Ceralasertib formate induces cell senescence. Ceralasertib formate shows antitumor activity[1][2].
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Ceralasertib formate | Ceralasertib formate is a potent, selective and orally active ATR inhibitor with an IC50 value of 1 nM. Ceralasertib formate inhibits cell viability and induces DNA damage. Ceralasertib formate induces cell senescence. Ceralasertib formate shows antitumor activity. | |||||||||||||||||||||
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References
- [1]. Vendetti FP, et al. The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo. Oncotarget. 2015 Dec 29;6(42):44289-305. [Content Brief]
- [2]. Kim HJ, et al. Anti-tumor activity of the ATR inhibitor AZD6738 in HER2 positive breast cancer cells. Int J Cancer. 2017 Jan 1;140(1):109-119. [Content Brief]
