1352286-61-3
1352286-61-3
Chemical Structure
NCATS-SM4420
- CAS No.: 1352286-61-3
- Formula:C31H27N3O5
- Molecular Weight:521.56
InChIKey: XFZVGZXCISTQLD-UHFFFAOYSA-N
SMILES: O=C(C)NC1=CC=C(C=C1)OCC2=C(OC)C=CC(C3=NC4=C(C(N3CC5=CC=CC=C5)=O)C(O)=CC=C4)=C2
Biological Activity: NCATS-SM4420 (Compound A35) is an orally active thyroid-stimulating hormone receptor (TSHR) ligand that inhibits the proliferation of MDA-T32 and MDA-T85 cells in vitro (IC50 values of 0.71 μM and 0.38 μM, respectively) and suppresses metastasis of MDA-T85F1 in mice. NCATS-SM4420 holds promise for research in the field of thyroid cancer[1].
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NCATS-SM4420 | NCATS-SM4420 (Compound A35) is an orally active thyroid-stimulating hormone receptor (TSHR) ligand that inhibits the proliferation of MDA-T32 and MDA-T85 cells in vitro (IC50 values of 0.71 μM and 0.38 μM, respectively) and suppresses metastasis of MDA-T85F1 in mice. NCATS-SM4420 holds promise for research in the field of thyroid cancer. | |||||||||||||||||||||
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