1352792-16-5
Chemical Structure
Alimemazine-d6 hydrochloride
Synonym(s): Trimeprazine-d6 hydrochloride
- CAS No.: 1352792-16-5
- Formula:C18H17D6ClN2S
- Molecular Weight:340.94
InChIKey: QUVSTPKPFAPBQU-HVTBMTIBSA-N
SMILES: CC(CN1C2=C(SC3=CC=CC=C31)C=CC=C2)CN(C([2H])([2H])[2H])C([2H])([2H])[2H].Cl
Biological Activity: Alimemazine-d6 hydrochloride (Trimeprazine-d6 hydrochloride) is the deuterium labeled Alimemazine (HY-12752). Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays antiserotonin, antispasmodic, and antiemetic properties[1][2].
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Alimemazine-d6 hydrochloride | Alimemazine-d6 hydrochloride (Trimeprazine-d6 hydrochloride) is the deuterium labeled Alimemazine (HY-12752). Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays antiserotonin, antispasmodic, and antiemetic properties. | |||||||||||||||||||||
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References
- [1]. Kuznetsova A, et al. Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice. JCI Insight. 2016;1(3). [Content Brief]
- [2]. Singh B, et al. Bioanalytical method development and validation of alimemazine in human plasma by LC-MS/MS and its application in bioequivalence studies. J Pharm Bioallied Sci. 2013 Oct;5(4):257-64. [Content Brief]
