135383-64-1
135383-64-1
Chemical Structure
Clathrodin
- CAS No.: 135383-64-1
- Formula:C11H13N5O
- Molecular Weight:231.25
IUPAC Name: (E)-N-(3-(2-amino-1H-imidazol-5-yl)allyl)-1H-pyrrole-2-carboxamide
InChIKey: PJKFCZYTTBYEHL-HNQUOIGGSA-N
SMILES: O=C(NC/C=C/C1=CN=C(N1)N)C2=CC=CN2
Biological Activity: Clathrodin is a voltage-gated sodium channel modulator that modulates channel activity and reduces inward sodium current. Clathrodin can be used in research related to neurological diseases[1][2][3][4][5].
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Clathrodin | Clathrodin is a voltage-gated sodium channel modulator that modulates channel activity and reduces inward sodium current. Clathrodin can be used in research related to neurological diseases. | |||||||||||||||||||||
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References
- [1]. Zidar N, et al. Antimicrobial activity of the marine alkaloids, clathrodin and oroidin, and their synthetic analogues. Marine drugs. 2014 Feb 14;12(2):940-63.
- [2]. Lillsunde KE, et al. Marine alkaloid oroidin analogues with antiviral potential: A novel class of synthetic compounds targeting the cellular chaperone Hsp90. Chemical biology & drug design. 2017 Dec;90(6):1147-1154.
- [3]. Peigneur S, et al. Action of clathrodin and analogues on voltage-gated sodium channels. Marine drugs. 2014 Apr 04;12(4):2132-43.
- [4]. Zidar N, et al. Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels. European journal of medicinal chemistry. 2017 Oct 20;139:232-241. [Content Brief]
- [5]. Hodnik Ž, et al. Novel state-dependent voltage-gated sodium channel modulators, based on marine alkaloids from Agelas sponges. European journal of medicinal chemistry. 2013;70:154-64.
