1354030-52-6
Chemical Structure
UNC9995
- CAS No.: 1354030-52-6
- Formula:C20H21Cl2N3OS
- Molecular Weight:422.37
IUPAC Name: 5-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propoxy)benzo[d]thiazole
InChIKey: VBHBKXBUHHJVBZ-UHFFFAOYSA-N
SMILES: ClC1=CC=CC(N2CCN(CC2)CCCOC3=CC4=C(C=C3)SC=N4)=C1Cl
Biological Activity: UNC9995 is a β-arrestin2-biased agonist of dopamine receptor Drd2. UNC9995 inhibits NLRP3 inflammasome activation by enhancing β-arrestin2-NLRP3 interaction, thus prevents neuronal degeneration. Futhermore, UNC9995 activates the Drd2/β-arrestin2 signaling to prevent inflammation-related genes transcription-induced by JAK/STAT3. UNC9995 improves depressive behavior in mouse model, and improves astrocytes dysfunctions[1].
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UNC9995 | 99.93% | UNC9995 is a β-arrestin2-biased agonist of dopamine receptor Drd2. UNC9995 inhibits NLRP3 inflammasome activation by enhancing β-arrestin2-NLRP3 interaction, thus prevents neuronal degeneration. Futhermore, UNC9995 activates the Drd2/β-arrestin2 signaling to prevent inflammation-related genes transcription-induced by JAK/STAT3. UNC9995 improves depressive behavior in mouse model, and improves astrocytes dysfunctions. | ||||||||||||||||||||
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