1354799-87-3
1354799-87-3
Chemical Structure
Ilginatinib maleate
Synonym(s): NS-018 maleate
- CAS No.: 1354799-87-3
- Formula:C25H24FN7O4
- Molecular Weight:505.50
IUPAC Name: (S)-N2-(1-(4-fluorophenyl)ethyl)-4-(1-methyl-1H-pyrazol-4-yl)-N6-(pyrazin-2-yl)pyridine-2,6-diamine maleate
InChIKey: OVAGJAAQMBYZDS-FXSDFHGDSA-N
SMILES: CN1N=CC(C2=CC(N[C@H](C3=CC=C(F)C=C3)C)=NC(NC4=NC=CN=C4)=C2)=C1.O=C(O)/C=C\C(O)=O
Biological Activity: Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable JAK2 inhibitor, with an IC50 of 0.72 nM, 46-, 54-, and 31-fold selectivity for JAK2 over JAK1 (IC50, 33 nM), JAK3 (IC50, 39 nM), and Tyk2 (IC50, 22 nM).
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ilginatinib maleate | 99.33% | Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable JAK2 inhibitor, with an IC50 of 0.72 nM, 46-, 54-, and 31-fold selectivity for JAK2 over JAK1 (IC50, 33 nM), JAK3 (IC50, 39 nM), and Tyk2 (IC50, 22 nM). | ||||||||||||||||||||
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