1354955-67-1
1354955-67-1
Chemical Structure
GNE-293
- CAS No.: 1354955-67-1
- Formula:C28H36N8O4S
- Molecular Weight:580.70
IUPAC Name: 4-(3-((2-(2-isopropyl-1H-benzo[d]imidazol-1-yl)-9-methyl-6-morpholino-9H-purin-8-yl)oxy)azetidin-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide
InChIKey: XRLOEZGWBZHADC-UHFFFAOYSA-N
SMILES: CC(C)C1=NC(C=CC=C2)=C2N1C3=NC4=C(N=C(OC5CN(C6CCS(CC6)(=O)=O)C5)N4C)C(N7CCOCC7)=N3
Biological Activity: GNE-293 is a potent and selective PI3Kδ inhibitor (IC50 = 4.38 nM). GNE-293 has favorable pharmacokinetic properties. GNE-293 can be used for research of asthma, rheumatoid arthritis, and other inflammatory disorders[1].
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GNE-293 | GNE-293 is a potent and selective PI3Kδ inhibitor (IC50 = 4.38 nM). GNE-293 has favorable pharmacokinetic properties. GNE-293 can be used for research of asthma, rheumatoid arthritis, and other inflammatory disorders. | |||||||||||||||||||||
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