135558-11-1
135558-11-1
Chemical Structure
Lobaplatin
Synonym(s): D-19466
- CAS No.: 135558-11-1
- Formula:C9H18N2O3Pt
- Molecular Weight:397.33
InChIKey: RLXPIABKJFUYFG-UHFFFAOYSA-M
SMILES: CC1[O-][Pt+2]2([O-]C1=O)[NH2]CC(CC3)C3C[NH2]2
Biological Activity: Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin arrests cell cycle at G1 and G2/M phase. Lobaplatin induces apoptosis by increasing expressions of caspase and Bax, decreasing expression of Bcl-2. Lobaplatin can be used for research of cancer[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Lobaplatin | 98.0% | Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin arrests cell cycle at G1 and G2/M phase. Lobaplatin induces apoptosis by increasing expressions of caspase and Bax, decreasing expression of Bcl-2. Lobaplatin can be used for research of cancer. | ||||||||||||||||||||
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References
- [1]. Du L, et, al. Antitumor activity of Lobaplatin against esophageal squamous cell carcinoma through caspase-dependent apoptosis and increasing the Bax/Bcl-2 ratio. Biomed Pharmacother. 2017 Nov;95:447-452. [Content Brief]
- [2]. Wu Q, et, al. Lobaplatin arrests cell cycle progression in human hepatocellular carcinoma cells. J Hematol Oncol. 2010 Oct 31;3:43. [Content Brief]
- [3]. McKeage MJ. Lobaplatin: a new antitumour platinum drug. Expert Opin Investig Drugs. 2001 Jan;10(1):119-28. [Content Brief]
