1357164-95-4
Chemical Structure
KUS187
- CAS No.: 1357164-95-4
- Formula:C27H25N4NaO5S
- Molecular Weight:540.57
IUPAC Name: (E)-4-amino-3-((6-(2-butoxy-3-formyl-5-methylphenyl)pyridin-3-yl)diazenyl)naphthalene-1-sulfonic acid, sodium salt
InChIKey: RFLXCPHNYHBVID-FJISBNMDSA-M
SMILES: O=CC1=CC(C)=CC(C2=NC=C(C=C2)/N=N/C3=C(N)C4=C(C=CC=C4)C(S(=O)(O[Na])=O)=C3)=C1OCCCC
Biological Activity: KUS187 is an orally active VCP ATPase modulator that inhibits VCP ATPase activity and reduces cellular ATP consumption. KUS187 prevents MPP+, low Glucose (D-Glucose) (HY-B0389)-, and Tunicamycin (HY-A0098)-induced cytoplasmic and mitochondrial ATP depletion. KUS187 inhibits ER stress, suppresses AMPK activation, prevents loss of mitochondrial membrane potential and changes in mitophagy, and protects neurons from MPP+-induced death/neurite retraction. KUS187 can be used for research on Parkinson's disease, retinitis pigmentosa, and retinal ganglion cell injury[1][2][3].
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KUS187 | KUS187 is an orally active VCP ATPase modulator that inhibits VCP ATPase activity and reduces cellular ATP consumption. KUS187 prevents MPP+, low Glucose (D-Glucose) (HY-B0389)-, and Tunicamycin (HY-A0098)-induced cytoplasmic and mitochondrial ATP depletion. KUS187 inhibits ER stress, suppresses AMPK activation, prevents loss of mitochondrial membrane potential and changes in mitophagy, and protects neurons from MPP+-induced death/neurite retraction. KUS187 can be used for research on Parkinson's disease, retinitis pigmentosa, and retinal ganglion cell injury. | |||||||||||||||||||||
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References
- [1]. Nakano M, et al. ATP Maintenance via Two Types of ATP Regulators Mitigates Pathological Phenotypes in Mouse Models of Parkinson's Disease. EBioMedicine. 2017 Aug;22:225-241.
- [2]. Ikeda HO, et al. Novel VCP modulators mitigate major pathologies of rd10, a mouse model of retinitis pigmentosa. Scientific reports. 2014 Aug 06;4:5970.
- [3]. Kusaka M, et al. Involvement of endothelins in neuroprotection of valosin-containing protein modulators against retinal ganglion cell damage. Scientific reports. 2022 Sep 28;12(1):16156. [Content Brief]
