1357471-57-8
1357471-57-8
Chemical Structure
TJ-M2010-5
- CAS No.: 1357471-57-8
- Formula:C23H26N4OS
- Molecular Weight:406.54
IUPAC Name: 3-(4-benzylpiperazin-1-yl)-N-(4-phenylthiazol-2-yl)propanamide
InChIKey: DTIQJBUDKQVBLT-UHFFFAOYSA-N
SMILES: O=C(NC1=NC(C2=CC=CC=C2)=CS1)CCN3CCN(CC4=CC=CC=C4)CC3
Biological Activity: TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain of MyD88 to interfere with its homodimerization, and the TLR/MyD88 signal pathway[1][2]. TJ-M2010-5 can be used for the research of myocardial ischemia/reperfusion injury (MIRI)[2].
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TJ-M2010-5 | 99.94% | TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain of MyD88 to interfere with its homodimerization, and the TLR/MyD88 signal pathway. TJ-M2010-5 can be used for the research of myocardial ischemia/reperfusion injury (MIRI). | ||||||||||||||||||||
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TJ-M2010-5 (Standard) | ≥98% | TJ-M2010-5 (Standard) is the analytical standard of TJ-M2010-5 (HY-139397). This product is intended for research and analytical applications. TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain of MyD88 to interfere with its homodimerization, and the TLR/MyD88 signal pathway. TJ-M2010-5 can be used for the research of myocardial ischemia/reperfusion injury (MIRI). | ||||||||||||||||||||
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References
- [1]. Lin Xie, et al. Targeting of MyD88 Homodimerization by Novel Synthetic Inhibitor TJ-M2010-5 in Preventing Colitis-Associated Colorectal Cancer. J Natl Cancer Inst. 2015 Dec 28;108(4):djv364. [Content Brief]
- [2]. Yan Miao,et al. Inhibition of MyD88 by a novel inhibitor reverses two-thirds of the infarct area in myocardial ischemia and reperfusion injury.Am J Transl Res. 2020 Sep 15;12(9):5151-5169. [Content Brief]
