1359416-20-8
1359416-20-8
Chemical Structure
P2L-003
- CAS No.: 1359416-20-8
- Formula:C23H25ClN4O3S
- Molecular Weight:472.99
InChIKey: ACFJCDVCHAVTDF-UHFFFAOYSA-N
SMILES: ClC1=C(CS(N2CC(C(CN(C(C)=O)C3=CC=CC=C3)=NN4C)=C4CC2)(=O)=O)C=CC=C1
Biological Activity: P2L-003 is a selective PAR2 antagonist with an IC50 of 0.62 μM in HT-29 cells. P2L-003 blocks PAR2-mediated Ca2+ mobilization without affecting PAR1, PAR4, or ATP-mediated signaling and dose-dependently suppresses the downstream MAPK signaling cascades, including ERK1/2 and p38 phosphorylation. P2L-003 can be used for colon cancer research[1].
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P2L-003 | P2L-003 is a selective PAR2 antagonist with an IC50 of 0.62 μM in HT-29 cells. P2L-003 blocks PAR2-mediated Ca2+ mobilization without affecting PAR1, PAR4, or ATP-mediated signaling and dose-dependently suppresses the downstream MAPK signaling cascades, including ERK1/2 and p38 phosphorylation. P2L-003 can be used for colon cancer research. | |||||||||||||||||||||
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