1359627-33-0
1359627-33-0
Chemical Structure
P516-0475
- CAS No.: 1359627-33-0
- Formula:C15H17N5O3
- Molecular Weight:315.33
IUPAC Name: N-(3-methoxypropyl)-7-methyl-4-oxo-4,5-dihydro-[1,2,3]triazolo[1,5-a]quinoxaline-3-carboxamide
InChIKey: IFMRJCJHUJEJJY-UHFFFAOYSA-N
SMILES: O=C(C1=C2N(N=N1)C3=C(C=C(C)C=C3)NC2=O)NCCCOC
Biological Activity: P516-0475 is an uncompetitive inhibitor against endopeptidase PepO. P516-0475 is also an agonist of the Rgg2/3 system with antibacterial activity. P516-0475 induces expression of Rgg2/3-regulated genes in the presence of short hydrophobic pheromone (SHP) for activity and leads to positive modulation of lysozyme resistance[1][2].
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P516-0475 | P516-0475 is an uncompetitive inhibitor against endopeptidase PepO. P516-0475 is also an agonist of the Rgg2/3 system with antibacterial activity. P516-0475 induces expression of Rgg2/3-regulated genes in the presence of short hydrophobic pheromone (SHP) for activity and leads to positive modulation of lysozyme resistance. | |||||||||||||||||||||
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References
- [1]. Morales T G P, et al. A novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO[J]. Journal of Biological Chemistry, 2018, 293(3): 931-940. [Content Brief]
- [2]. Nepomuceno VM, et al. A Streptomyces tendae Specialized Metabolite Inhibits Quorum Sensing in Group A Streptococcus. Microbiol Spectr. 2023 Aug 17;11(4):e0527922. [Content Brief]
