1362150-16-0
1362150-16-0
Chemical Structure
Nampt-IN-20
- CAS No.: 1362150-16-0
- Formula:C21H17N3O3S
- Molecular Weight:391.45
IUPAC Name: N-(4-(phenylsulfonyl)benzyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide
InChIKey: LGQSNALVWIMFPP-UHFFFAOYSA-N
SMILES: O=C(NCC1=CC=C(C=C1)S(=O)(=O)C=2C=CC=CC2)C3=CC=4C=NC=CC4N3
Biological Activity: Nampt-IN-20 is a nicotinamide phosphoribosyltransferase (Nampt) inhibitor with a IC50 of 9.0 nM. Nampt-IN-20 binds to the active site of Nampt, occupies the NAM-binding region and disrupts NAD biosynthesis. Nampt-IN-20 exerts antiproliferative effects in A2780 ovarian cancer cells. Nampt-IN-20 can be used for the research of ovarian cancer[1].
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Nampt-IN-20 | 95.93% | Nampt-IN-20 is a nicotinamide phosphoribosyltransferase (Nampt) inhibitor with a IC50 of 9.0 nM. Nampt-IN-20 binds to the active site of Nampt, occupies the NAM-binding region and disrupts NAD biosynthesis. Nampt-IN-20 exerts antiproliferative effects in A2780 ovarian cancer cells. Nampt-IN-20 can be used for the research of ovarian cancer. | ||||||||||||||||||||
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