1364692-88-5
Chemical Structure
AMPK activator 18
- CAS No.: 1364692-88-5
- Formula:C26H18ClN3O4
- Molecular Weight:471.90
IUPAC Name: 5-((6-chloro-5-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-1H-imidazo[4,5-b]pyridin-2-yl)oxy)-2-methylbenzoic acid
InChIKey: MEZQZPGDJJEQPZ-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC(OC2=NC3=NC(=C(Cl)C=C3N2)C4=CC=C(C=C4)C5=CC=CC=C5O)=CC=C1C
Biological Activity: AMPK activator 18 is a potent allosteric activator of AMPK complexes containing the β2 isoform. AMPK activator 18activates α2-containing AMPK α2β2γ1 and α2β2γ3 complexes, with EC50 values of 17.2 and 82.1 nM. AMPK activator 18 stimulates β2-AMPK in cells, and glucose uptake by isolated skeletal muscle. AMPK activator 18 induces acetyl-coenzyme A carboxylase (ACC) and AMPK α-T172 phosphorylation. AMPK activator 18 can be used for the research of type 2 diabetes[1].
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AMPK activator 18 | AMPK activator 18 is a potent allosteric activator of AMPK complexes containing the β2 isoform. AMPK activator 18activates α2-containing AMPK α2β2γ1 and α2β2γ3 complexes, with EC50 values of 17.2 and 82.1 nM. AMPK activator 18 stimulates β2-AMPK in cells, and glucose uptake by isolated skeletal muscle. AMPK activator 18 induces acetyl-coenzyme A carboxylase (ACC) and AMPK α-T172 phosphorylation. AMPK activator 18 can be used for the research of type 2 diabetes. | |||||||||||||||||||||
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