136696-10-1
Chemical Structure
12-Oxo-leukotriene B4
Synonym(s): 12-Oxo-LTB4
- CAS No.: 136696-10-1
- Formula:C20H30O4
- Molecular Weight:334.45
IUPAC Name: (S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid
InChIKey: SJVWVCVZWMJXOK-NOJHDUNKSA-N
SMILES: CCCCC/C=C\CC(/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O)=O
Biological Activity: 12-Oxo-leukotriene B4 (12-Oxo-LTB4) is an intermediate in the lipoxygenase-catalyzed path of Arachidonic acid (HY-109590) metabolism. 12-Oxo-leukotriene B4 is crucial in Leukotriene B4 metabolism and is involved in inflammation reactions[1]. 12-Oxo-leukotriene B4 stimulates calcium levels in human neutrophils with an EC50 of 33 nM. 12-Oxo-leukotriene B4 induces migration of neutrophils with EC50 of 170 nM[2].
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12-Oxo-leukotriene B4 | 12-Oxo-leukotriene B4 (12-Oxo-LTB4) is an intermediate in the lipoxygenase-catalyzed path of Arachidonic acid (HY-109590) metabolism. 12-Oxo-leukotriene B4 is crucial in Leukotriene B4 metabolism and is involved in inflammation reactions. 12-Oxo-leukotriene B4 stimulates calcium levels in human neutrophils with an EC50 of 33 nM. 12-Oxo-leukotriene B4 induces migration of neutrophils with EC50 of 170 nM. | |||||||||||||||||||||
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References
- [1]. Khanapure S P, et al., 12-Oxo-LTB4, a key pivotal intermediate in LTB4 metabolism[J]. The Journal of Organic Chemistry, 1995, 60(6): 1806-1813.
- [2]. Powell WS, et al., Effects of metabolites of leukotriene B4 on human neutrophil migration and cytosolic calcium levels. J Pharmacol Exp Ther. 1996 Feb;276(2):728-36. [Content Brief]
