136777-43-0
Chemical Structure
Carvotroline hydrochloride
- CAS No.: 136777-43-0
- Formula:C18H19ClFN3
- Molecular Weight:331.81
IUPAC Name: 8-fluoro-2-(2-(pyridin-4-yl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride
InChIKey: CYAQJBUCOCJWET-UHFFFAOYSA-N
SMILES: FC1=CC2=C(NC3=C2CN(CC3)CCC4=CC=NC=C4)C=C1.Cl
Biological Activity: Carvotroline hydrochloride is an antipsychotic agent and 5-HT2 receptor antagonist, with a Ki value of 211 nM for the 5-HT2 receptor. Carvotroline hydrochloride modulates the activity of the stress-related hypothalamic-pituitary-adrenal axis. Carvotroline hydrochloride exerts a stronger blocking effect on Apomorphine (HY-12723)-induced climbing behavior than on Apomorphine-induced stereotyped behavior. Carvotroline hydrochloride inhibits conditioned avoidance responses in rats and monkeys without inducing catalepsy. Carvotroline hydrochloride can be used in studies related to schizophrenia[1][2].
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Carvotroline hydrochloride | Carvotroline hydrochloride is an antipsychotic agent and 5-HT2 receptor antagonist, with a Ki value of 211 nM for the 5-HT2 receptor. Carvotroline hydrochloride modulates the activity of the stress-related hypothalamic-pituitary-adrenal axis. Carvotroline hydrochloride exerts a stronger blocking effect on Apomorphine (HY-12723)-induced climbing behavior than on Apomorphine-induced stereotyped behavior. Carvotroline hydrochloride inhibits conditioned avoidance responses in rats and monkeys without inducing catalepsy. Carvotroline hydrochloride can be used in studies related to schizophrenia. | |||||||||||||||||||||
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References
- [1]. Abou-Gharbia M. Discovery of innovative small molecule therapeutics[J]. Journal of Medicinal Chemistry, 2009, 52(1): 2-9.
- [2]. Matheson GK, et al. Modification of hypothalamic-pituitary-adrenocortical activity by serotonergic agents in the rat. Pharmacology. 1997 Aug;55(2):59-65. [Content Brief]
