136904-69-3
136904-69-3
Chemical Structure
2′-Thioadenosine
Synonym(s): PD157432
- CAS No.: 136904-69-3
- Formula:C10H13N5O3S
- Molecular Weight:283.31
IUPAC Name: (2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-(hydroxymethyl)-4-mercaptotetrahydrofuran-3-ol
InChIKey: VLRCFULRQZKFRM-KQYNXXCUSA-N
SMILES: NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3S)C2=NC=N1
Biological Activity: 2'-Thioadenosine (PD157432) is a selective and irreversible inhibitor of ErbB-1 and ErbB-2, with an IC50 of 45 µM for ErbB-2. 2'-Thioadenosine covalently inactivates ErbB-1 via modification of a cysteine residue at the active site[1].
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2′-Thioadenosine | 2'-Thioadenosine (PD157432) is a selective and irreversible inhibitor of ErbB-1 and ErbB-2, with an IC50 of 45 µM for ErbB-2. 2'-Thioadenosine covalently inactivates ErbB-1 via modification of a cysteine residue at the active site. | |||||||||||||||||||||
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