136982-36-0
Chemical Structure
CP-99994
- CAS No.: 136982-36-0
- Formula:C19H24N2O
- Molecular Weight:296.41
IUPAC Name: (2S,3S)-N-(2-methoxybenzyl)-2-phenylpiperidin-3-amine
InChIKey: DTQNEFOKTXXQKV-HKUYNNGSSA-N
SMILES: COC(C=CC=C1)=C1CN[C@@H]2[C@H](C3=CC=CC=C3)NCCC2
Biological Activity: CP-99994 is a Tachykinin neurokinin 1 (NK-1) receptor antagonist with a Ki of 0.25 nM. CP-99994 prevents colorectal sensitization in the context of visceral hypersensitivity. CP-99994 reduces colorectal hypersensitivity induced by acetic acid injections in a model of bladder-colon cross-sensitization. CP-99994 hydrochloride attenuates the neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity[1].
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CP-99994 | CP-99994 is a Tachykinin neurokinin 1 (NK-1) receptor antagonist with a Ki of 0.25 nM. CP-99994 prevents colorectal sensitization in the context of visceral hypersensitivity. CP-99994 reduces colorectal hypersensitivity induced by acetic acid injections in a model of bladder-colon cross-sensitization. CP-99994 hydrochloride attenuates the neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity. | |||||||||||||||||||||
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