1373625-34-3
1373625-34-3
Chemical Structure
ARN 077
Synonym(s): URB913
- CAS No.: 1373625-34-3
- Formula:C16H21NO4
- Molecular Weight:291.34
IUPAC Name: 5-phenylpentyl ((2S,3R)-2-methyl-4-oxooxetan-3-yl)carbamate
InChIKey: PTVDTLVLQXSSEC-GXTWGEPZSA-N
SMILES: O=C(OCCCCCC1=CC=CC=C1)N[C@@H]2[C@H](C)OC2=O
Biological Activity: ARN 077 is a potent and selective N-acylethanolamine acid amidase (NAAA) inhibitor with an IC50 of 7 nM for human NAAA[1]. ARN 077 significantly increases palmitoyl ethanolamine (PEA) levels within the CNS and has broad antinociceptive activity in mice and rats[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
ARN 077 | 99.82% | ARN 077 is a potent and selective N-acylethanolamine acid amidase (NAAA) inhibitor with an IC50 of 7 nM for human NAAA. ARN 077 significantly increases palmitoyl ethanolamine (PEA) levels within the CNS and has broad antinociceptive activity in mice and rats. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Sasso O, et al. Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models. Pain. 2013 Mar;154(3):350-60. [Content Brief]
- [2]. Davis MP, et al. Cannabinoids in pain management: CB1, CB2 and non-classic receptor ligands. Expert Opin Investig Drugs. 2014 Aug;23(8):1123-40. [Content Brief]
