13739-02-1
Chemical Structure
Diacerein
Synonym(s): Diacerhein; Diacetylrhein
- CAS No.: 13739-02-1
- Formula:C19H12O8
- Molecular Weight:368.29
IUPAC Name: 4,5-diacetoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid
InChIKey: TYNLGDBUJLVSMA-UHFFFAOYSA-N
SMILES: O=C(C(C=C1C2=O)=CC(OC(C)=O)=C1C(C3=C2C=CC=C3OC(C)=O)=O)O
Biological Activity: Diacerein (Diacerhein), an orally active anthraquinone, reduces production of IL-1 converting enzyme then inhibits the activation of IL-1β by related downstream signaling. Diacerein is an anti-inflammatory and anti-rheumatic drug. Diacerein can relieve bronchospasm and control airway inflammation in asthmatic mice. Diacerein has the potential for slow acting drug in osteoarthritis (SYSADOA) research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Diacerein | 98.64% | Diacerein (Diacerhein), an orally active anthraquinone, reduces production of IL-1 converting enzyme then inhibits the activation of IL-1β by related downstream signaling. Diacerein is an anti-inflammatory and anti-rheumatic drug. Diacerein can relieve bronchospasm and control airway inflammation in asthmatic mice. Diacerein has the potential for slow acting drug in osteoarthritis (SYSADOA) research. | ||||||||||||||||||||
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Diacerein (Standard) | ≥98% | Diacerein (Standard) is the analytical standard of Diacerein. This product is intended for research and analytical applications. Diacerein (Diacerhein), a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases. | ||||||||||||||||||||
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Diacerein-d6 | Diacerein-d6 is the deuterium labeled Diacerein. Diacerein (Diacerhein), a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases. | |||||||||||||||||||||
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References
- [1]. Birgit Lohberger, et al. Diacerein retards cell growth of chondrosarcoma cells at the G2/M cell cycle checkpoint via cyclin B1/CDK1 and CDK2 downregulation. BMC Cancer. 2015 Nov 10:15:891. [Content Brief]
- [2]. Shi S, Xue L, Han S, et al. Anti-Contractile and Anti-Inflammatory Effects of Diacerein on Isolated Mouse Airways Smooth Muscle and Mouse Asthma Model. Front Pharmacol. 2020;11:560361. [Content Brief]
- [3]. Eleni Douni, et al. Attenuation of inflammatory polyarthritis in TNF transgenic mice by diacerein: comparative analysis with dexamethasone, methotrexate and anti-TNF protocols. Arthritis Res Ther. 2004;6(1):R65-R72. [Content Brief]
