1374647-07-0
Chemical Structure
L505-yne
- CAS No.: 1374647-07-0
- Formula:C52H64N4O7
- Molecular Weight:857.11
IUPAC Name: tert-butyl ((2S,3R,5R)-6-(((S)-1-(((S)-3-(4-benzoylphenyl)-1-(hex-5-yn-1-ylamino)-1-oxopropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl)carbamate
InChIKey: YKCNMCSQOOEJHB-BDHQKZEVSA-N
SMILES: [C@@H](CC1=CC=CC=C1)(C[C@H]([C@H](CC2=CC=CC=C2)NC(OC(C)(C)C)=O)O)C(N[C@H](C(N[C@@H](CC3=CC=C(C(=O)C4=CC=CC=C4)C=C3)C(NCCCCC#C)=O)=O)CC(C)C)=O
Biological Activity: L505-yne is an active site-directed γ-secretase inhibitor. L505-yne blocks photoaffinity labeling of PS1-NTF, PS1-CTF, and SPP by clickable GSI photoprobes, binds the γ-secretase complex and inhibits Aβ42 production. L458-BPyne can be used for the research of Alzheimer’s disease[1][2].
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L505-yne | L505-yne is an active site-directed γ-secretase inhibitor. L505-yne blocks photoaffinity labeling of PS1-NTF, PS1-CTF, and SPP by clickable GSI photoprobes, binds the γ-secretase complex and inhibits Aβ42 production. L458-BPyne can be used for the research of Alzheimer’s disease. | |||||||||||||||||||||
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References
- [1]. Crump CJ, et al. Development of clickable active site-directed photoaffinity probes for γ-secretase. Bioorg Med Chem Lett. 2012;22(8):2997-3000. [Content Brief]
- [2]. Ballard TE, et al. Investigating γ-secretase protein interactions in live cells using active site-directed clickable dual-photoaffinity probesMed. Chem. Commun. 2013 Nov 04;5:321-327.
