1375557-33-7
1375557-33-7
Chemical Structure
A-1293201
- CAS No.: 1375557-33-7
- Formula:C21H23N3O3
- Molecular Weight:365.43
IUPAC Name: (S)-N-(4-(((tetrahydrofuran-3-yl)methyl)carbamoyl)phenyl)isoindoline-2-carboxamide
InChIKey: BLZJCPAXCWJANZ-HNNXBMFYSA-N
SMILES: O=C(N1CC2=C(C=CC=C2)C1)NC3=CC=C(C(NC[C@H]4COCC4)=O)C=C3
Biological Activity: A-1293201 is a substrate-independent NAMPT inhibitor with antitumor activity. A-1293201 effectively reduces the total cellular NAD+/NADH (NADt) level, subsequently leading to ATP depletion and cancer cell death. In addition, A-1293201 can effectively overcome the acquired resistance mechanism of the NAMPT Y18 mutant to CHS-828 (HY-10079)[1].
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A-1293201 | 99.82% | A-1293201 is a substrate-independent NAMPT inhibitor with antitumor activity. A-1293201 effectively reduces the total cellular NAD+/NADH (NADt) level, subsequently leading to ATP depletion and cancer cell death. In addition, A-1293201 can effectively overcome the acquired resistance mechanism of the NAMPT Y18 mutant to CHS-828 (HY-10079). | ||||||||||||||||||||
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