1375752-78-5
1375752-78-5
Chemical Structure
BMS-984923
- CAS No.: 1375752-78-5
- Formula:C22H15ClN2O2
- Molecular Weight:374.82
IUPAC Name: (4R,5R)-5-(2-chlorophenyl)-4-(5-(phenylethynyl)pyridin-3-yl)oxazolidin-2-one
InChIKey: IAYVUQJOKDFLAL-NHCUHLMSSA-N
SMILES: O=C1O[C@H](C2=CC=CC=C2Cl)[C@@H](C3=CC(C#CC4=CC=CC=C4)=CN=C3)N1
Biological Activity: BMS-984923, a potent mGluR5 silent allosteric modulator (SAM), with exquisite binding affinity (Ki = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Aβo signaling without affecting physiological glutamate signaling[1][2].
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BMS-984923 | 99.94% | BMS-984923, a potent mGluR5 silent allosteric modulator (SAM), with exquisite binding affinity (Ki = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Aβo signaling without affecting physiological glutamate signaling. | ||||||||||||||||||||
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References
- [1]. Laura T Haas, et al. Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer's Mouse Phenotypes. Cell Rep. 2017 Jul 5;20(1):76-88. [Content Brief]
- [2]. Hong Huang, et al. Oxazolidinone-based allosteric modulators of mGluR5: Defining molecular switches to create a pharmacological tool box. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4165-9. [Content Brief]
