13794-15-5
13794-15-5
Chemical Structure
Lactisole free acid
- CAS No.: 13794-15-5
- Formula:C10H12O4
- Molecular Weight:196.20
IUPAC Name: 2-(4-methoxyphenoxy)propanoic acid
InChIKey: MIEKOFWWHVOKQX-UHFFFAOYSA-N
SMILES: O=C(O)C(C)OC1=CC=C(OC)C=C1
Biological Activity: Lactisole free acid is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole free acid inhibits insulin secretion induced by glucose in mouse islets[1][2].
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Lactisole free acid | 99.75% | Lactisole free acid is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole free acid inhibits insulin secretion induced by glucose in mouse islets. | ||||||||||||||||||||
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Lactisole free acid (Standard) | ≥98% | Lactisole free acid (Standard) is the analytical standard of Lactisole free acid (HY-W030796). This product is intended for research and analytical applications. Lactisole free acid is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole free acid inhibits insulin secretion induced by glucose in mouse islets. | ||||||||||||||||||||
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References
- [1]. Hamano K, et al. Lactisole inhibits the glucose-sensing receptor T1R3 expressed in mouse pancreatic β-cells. J Endocrinol. 2015 Jul;226(1):57-66. [Content Brief]
- [2]. Schweiger K, et al. Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects. Nutrients. 2020 Oct 14;12(10):3133. [Content Brief]
