1379783-91-1
Chemical Structure
BMX-001
- CAS No.: 1379783-91-1
- Formula:C64H76Cl5MnN8O4
- Molecular Weight:1253.54
InChIKey: FVIXMTYHFFAYDY-UHFFFAOYSA-I
SMILES: CCCCOCC[N+]1=C(C=CC=C1)C2=C3C=CC4=C(C5=[N+](CCOCCCC)C=CC=C5)C6=[N]7[Mn+3]8([N-]34)[N-]9C(C(C%10=[N+](C=CC=C%10)CCOCCCC)=C%11C=CC2=[N]8%11)=CC=C9C(C%12=[N+](CCOCCCC)C=CC=C%12)=C7C=C6.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-]
Biological Activity: BMX-001 is a blood-brain barrier-penetrant, redox-active manganese porphyrin SOD mimetic with reactive oxygen species/reactive nitrogen species scavenging activity. BMX-001 inhibits NF-κB through S-glutathionylation, activates Nrf2/Keap1, and decreases TRPV1. BMX-001 enhances glucose-stimulated insulin secretion and inhibits islet apoptosis. BMX-001 radiosensitizes tumors, reduces cancer-associated fibroblasts, promotes dendritic cell maturation, modulates macrophage/MDSC/T cell responses, inhibits EMT/angiogenesis/hypoxia/inflammation, and induces apoptosis. BMX-001 protects glial cells while exerting pro-oxidant effects in cancer, and alleviates neuropathic pain. BMX-001 has neuroprotective effects in ischemic stroke. BMX-001 can be used for research on type 1 diabetes, ischemic stroke, pain, breast cancer, and glioblastoma[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BMX-001 | 85% | BMX-001 is a blood-brain barrier-penetrant, redox-active manganese porphyrin SOD mimetic with reactive oxygen species/reactive nitrogen species scavenging activity. BMX-001 inhibits NF-κB through S-glutathionylation, activates Nrf2/Keap1, and decreases TRPV1. BMX-001 enhances glucose-stimulated insulin secretion and inhibits islet apoptosis. BMX-001 radiosensitizes tumors, reduces cancer-associated fibroblasts, promotes dendritic cell maturation, modulates macrophage/MDSC/T cell responses, inhibits EMT/angiogenesis/hypoxia/inflammation, and induces apoptosis. BMX-001 protects glial cells while exerting pro-oxidant effects in cancer, and alleviates neuropathic pain. BMX-001 has neuroprotective effects in ischemic stroke. BMX-001 can be used for research on type 1 diabetes, ischemic stroke, pain, breast cancer, and glioblastoma. | ||||||||||||||||||||
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References
- [1]. Bruni A, et al. BMX-001, a novel redox-active metalloporphyrin, improves islet function and engraftment in a murine transplant model. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2018 Aug;18(8):1879-1889. [Content Brief]
- [2]. Pan T, et al. Therapeutic Potential of BMX-001 for Preventing Chemotherapy-Induced Peripheral Neuropathic Pain. Pharmaceuticals. 2025 Aug 5;18(8):1159.
- [3]. Noh SU, et al. Single-Cell Profiling Reveals Immune-Based Mechanisms Underlying Tumor Radiosensitization by a Novel Mn Porphyrin Clinical Candidate, MnTnBuOE-2-PyP (BMX-001). Antioxidants (Basel, Switzerland). 2024 Apr 17;13(4):477.
- [4]. Pan T, et al. Therapeutic Potential of BMX-001 for Preventing Chemotherapy-Induced Peripheral Neuropathic Pain. Pharmaceuticals (Basel, Switzerland). 2025 Aug 05;18(8):1159.
- [5]. Li X, et al. Intracarotid Infusion of Redox-Active Manganese Porphyrin, MnTnBuOE-2-PyP5+, following Reperfusion Improves Long-Term, 28-Day Post-Stroke Outcomes in Rats. Antioxidants. 2023 Oct 13;12(10):1861.
