1380078-95-4
Chemical Structure
Plazomicin sulfate
Synonym(s): ACHN 490 sulfate
- CAS No.: 1380078-95-4
- Formula:C25H48N6O10·5/2H2SO4
- Molecular Weight:837.87
SMILES: O[C@H]([C@H]([C@@](C)(O)CO1)NC)[C@@]1([H])O[C@H]2[C@@H](C[C@H](N)[C@@H](O[C@@]3([H])OC(CNCCO)=CC[C@H]3N)[C@@H]2O)NC([C@@H](O)CCN)=O.OS(O)(=O)=O.[2.5]
Biological Activity: Plazomicin (ACHN 490) sulfate is a semi-synthetic aminoglycoside Antibiotic. Plazomicin sulfate acts as a substrate for Aminoglycoside acetyltransferase and Aminoglycoside phosphotransferase. Plazomicin sulfaten is not modified by various common aminoglycoside-modifying enzymes. Plazomicin sulfate selectively inhibits MATE2-K. Plazomicin sulfate exhibits activity against multidrug-resistant bacteria, including carbapenem-resistant Enterobacterales[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Plazomicin sulfate | 98.0% | Plazomicin (ACHN 490) sulfate is a semi-synthetic aminoglycoside Antibiotic. Plazomicin sulfate acts as a substrate for Aminoglycoside acetyltransferase and Aminoglycoside phosphotransferase. Plazomicin sulfaten is not modified by various common aminoglycoside-modifying enzymes. Plazomicin sulfate selectively inhibits MATE2-K. Plazomicin sulfate exhibits activity against multidrug-resistant bacteria, including carbapenem-resistant Enterobacterales. | ||||||||||||||||||||
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References
- [1]. Clark JA, et al. Plazomicin: a new aminoglycoside in the fight against antimicrobial resistance. Ther Adv Infect Dis. 2020;7:2049936120952604. Published 2020 Sep 4. [Content Brief]
- [2]. Cox G, et al. Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes. ACS Infect Dis. 2018;4(6):980-987. [Content Brief]
