1380316-56-2
Chemical Structure
TPE-Cy
- CAS No.: 1380316-56-2
- Formula:C48H43NO3S
- Molecular Weight:713.92
InChIKey: XDAHFLSUULBFQT-MHTZHOPKSA-N
SMILES: O=S([O-])(CCCC[N+]1=C(/C=C/C2=CC=C(C3=CC=C(/C(C4=CC=CC=C4)=C(C5=CC=CC=C5)/C6=CC=CC=C6)C=C3)C=C2)C(C)(C)C7=C1C=CC=C7)=O
Biological Activity: TPE-Cy is a fluorescent probe with both aggregation-induced emission (AIE) property and pH-dependent luminescent behavior. TPE-Cy exhibits significant luminescent differences under different acidic and alkaline conditions: it shows moderate to strong red emission with linear variation with pH in acidic environments and within the pH range of 5-7, weak or even no emission within the pH range of 7-10, and switches to blue emission under alkaline conditions. TPE-Cy possesses excellent cell permeability and biocompatibility, enabling accurate ratiometric pH sensing and imaging monitoring in living cells via confocal microscopy, ratiometric analysis and flow cytometry[1][2].
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TPE-Cy | TPE-Cy is a fluorescent probe with both aggregation-induced emission (AIE) property and pH-dependent luminescent behavior. TPE-Cy exhibits significant luminescent differences under different acidic and alkaline conditions: it shows moderate to strong red emission with linear variation with pH in acidic environments and within the pH range of 5-7, weak or even no emission within the pH range of 7-10, and switches to blue emission under alkaline conditions. TPE-Cy possesses excellent cell permeability and biocompatibility, enabling accurate ratiometric pH sensing and imaging monitoring in living cells via confocal microscopy, ratiometric analysis and flow cytometry. | |||||||||||||||||||||
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References
- [1]. Chen S, et al. An AIE-active hemicyanine fluorogen with stimuli-responsive red/blue emission: extending the pH sensing range by “switch+ knob” effect[J]. Chemical Science, 2012, 3(6): 1804-1809.
- [2]. Chen S, et al. Full-range intracellular pH sensing by an aggregation-induced emission-active two-channel ratiometric fluorogen. Journal of the American Chemical Society. 2013 Apr 03;135(13):4926-9.
